Reactive oxygen species and induction of lignin peroxidase in Phanerochaete chrysosporium.
Identifieur interne : 000928 ( Main/Exploration ); précédent : 000927; suivant : 000929Reactive oxygen species and induction of lignin peroxidase in Phanerochaete chrysosporium.
Auteurs : Paula A. Belinky [Israël] ; Nufar Flikshtein ; Sergey Lechenko ; Shimon Gepstein ; Carlos G. DosoretzSource :
- Applied and environmental microbiology [ 0099-2240 ] ; 2003.
Descripteurs français
- KwdFr :
- AMP cyclique (métabolisme), Espèces réactives de l'oxygène (métabolisme), Induction enzymatique (MeSH), Milieux de culture (MeSH), Oxygène (pharmacologie), Peroxidases (biosynthèse), Peroxidases (génétique), Phanerochaete (croissance et développement), Phanerochaete (effets des médicaments et des substances chimiques), Phanerochaete (enzymologie), Phanerochaete (physiologie), Régulation de l'expression des gènes fongiques (MeSH), Stress oxydatif (MeSH), Transcription génétique (MeSH).
- MESH :
- biosynthèse : Peroxidases.
- croissance et développement : Phanerochaete.
- effets des médicaments et des substances chimiques : Phanerochaete.
- enzymologie : Phanerochaete.
- génétique : Peroxidases.
- métabolisme : AMP cyclique, Espèces réactives de l'oxygène.
- pharmacologie : Oxygène.
- physiologie : Phanerochaete.
- Induction enzymatique, Milieux de culture, Régulation de l'expression des gènes fongiques, Stress oxydatif, Transcription génétique.
English descriptors
- KwdEn :
- Culture Media (MeSH), Cyclic AMP (metabolism), Enzyme Induction (MeSH), Gene Expression Regulation, Fungal (MeSH), Oxidative Stress (MeSH), Oxygen (pharmacology), Peroxidases (biosynthesis), Peroxidases (genetics), Phanerochaete (drug effects), Phanerochaete (enzymology), Phanerochaete (growth & development), Phanerochaete (physiology), Reactive Oxygen Species (metabolism), Transcription, Genetic (MeSH).
- MESH :
- chemical , biosynthesis : Peroxidases.
- chemical , genetics : Peroxidases.
- chemical , metabolism : Cyclic AMP, Reactive Oxygen Species.
- chemical , pharmacology : Oxygen.
- chemical : Culture Media.
- drug effects : Phanerochaete.
- enzymology : Phanerochaete.
- growth & development : Phanerochaete.
- physiology : Phanerochaete.
- Enzyme Induction, Gene Expression Regulation, Fungal, Oxidative Stress, Transcription, Genetic.
Abstract
We studied oxidative stress in lignin peroxidase (LIP)-producing cultures (cultures flushed with pure O(2)) of Phanerochaete chrysosporium by comparing levels of reactive oxygen species (ROS), cumulative oxidative damage, and antioxidant enzymes with those found in non-LIP-producing cultures (cultures grown with free exchange of atmospheric air [control cultures]). A significant increase in the intracellular peroxide concentration and the degree of oxidative damage to macromolecules, e.g., DNA, lipids, and proteins, was observed when the fungus was exposed to pure O(2) gas. The specific activities of manganese superoxide dismutase, catalase, glutathione reductase, and glutathione peroxidase and the consumption of glutathione were all higher in cultures exposed to pure O(2) (oxygenated cultures) than in cultures grown with atmospheric air. Significantly higher gene expression of the LIP-H2 isozyme occurred in the oxygenated cultures. A hydroxyl radical scavenger, dimethyl sulfoxide (50 mM), added to the culture every 12 h, completely abolished LIP expression at the mRNA and protein levels. This effect was confirmed by in situ generation of hydroxyl radicals via the Fenton reaction, which significantly enhanced LIP expression. The level of intracellular cyclic AMP (cAMP) was correlated with the starvation conditions regardless of the oxygenation regimen applied, and similar cAMP levels were obtained at high O(2) concentrations and in cultures grown with atmospheric air. These results suggest that even though cAMP is a prerequisite for LIP expression, high levels of ROS, preferentially hydroxyl radicals, are required to trigger LIP synthesis. Thus, the induction of LIP expression by O(2) is at least partially mediated by the intracellular ROS.
DOI: 10.1128/aem.69.11.6500-6506.2003
PubMed: 14602606
PubMed Central: PMC262269
Affiliations:
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A significant increase in the intracellular peroxide concentration and the degree of oxidative damage to macromolecules, e.g., DNA, lipids, and proteins, was observed when the fungus was exposed to pure O(2) gas. The specific activities of manganese superoxide dismutase, catalase, glutathione reductase, and glutathione peroxidase and the consumption of glutathione were all higher in cultures exposed to pure O(2) (oxygenated cultures) than in cultures grown with atmospheric air. Significantly higher gene expression of the LIP-H2 isozyme occurred in the oxygenated cultures. A hydroxyl radical scavenger, dimethyl sulfoxide (50 mM), added to the culture every 12 h, completely abolished LIP expression at the mRNA and protein levels. This effect was confirmed by in situ generation of hydroxyl radicals via the Fenton reaction, which significantly enhanced LIP expression. The level of intracellular cyclic AMP (cAMP) was correlated with the starvation conditions regardless of the oxygenation regimen applied, and similar cAMP levels were obtained at high O(2) concentrations and in cultures grown with atmospheric air. These results suggest that even though cAMP is a prerequisite for LIP expression, high levels of ROS, preferentially hydroxyl radicals, are required to trigger LIP synthesis. Thus, the induction of LIP expression by O(2) is at least partially mediated by the intracellular ROS.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">14602606</PMID><DateCompleted><Year>2004</Year><Month>02</Month><Day>20</Day></DateCompleted><DateRevised><Year>2019</Year><Month>05</Month><Day>09</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0099-2240</ISSN><JournalIssue CitedMedium="Print"><Volume>69</Volume><Issue>11</Issue><PubDate><Year>2003</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Applied and environmental microbiology</Title><ISOAbbreviation>Appl Environ Microbiol</ISOAbbreviation></Journal><ArticleTitle>Reactive oxygen species and induction of lignin peroxidase in Phanerochaete chrysosporium.</ArticleTitle><Pagination><MedlinePgn>6500-6</MedlinePgn></Pagination><Abstract><AbstractText>We studied oxidative stress in lignin peroxidase (LIP)-producing cultures (cultures flushed with pure O(2)) of Phanerochaete chrysosporium by comparing levels of reactive oxygen species (ROS), cumulative oxidative damage, and antioxidant enzymes with those found in non-LIP-producing cultures (cultures grown with free exchange of atmospheric air [control cultures]). A significant increase in the intracellular peroxide concentration and the degree of oxidative damage to macromolecules, e.g., DNA, lipids, and proteins, was observed when the fungus was exposed to pure O(2) gas. The specific activities of manganese superoxide dismutase, catalase, glutathione reductase, and glutathione peroxidase and the consumption of glutathione were all higher in cultures exposed to pure O(2) (oxygenated cultures) than in cultures grown with atmospheric air. Significantly higher gene expression of the LIP-H2 isozyme occurred in the oxygenated cultures. A hydroxyl radical scavenger, dimethyl sulfoxide (50 mM), added to the culture every 12 h, completely abolished LIP expression at the mRNA and protein levels. This effect was confirmed by in situ generation of hydroxyl radicals via the Fenton reaction, which significantly enhanced LIP expression. The level of intracellular cyclic AMP (cAMP) was correlated with the starvation conditions regardless of the oxygenation regimen applied, and similar cAMP levels were obtained at high O(2) concentrations and in cultures grown with atmospheric air. These results suggest that even though cAMP is a prerequisite for LIP expression, high levels of ROS, preferentially hydroxyl radicals, are required to trigger LIP synthesis. Thus, the induction of LIP expression by O(2) is at least partially mediated by the intracellular ROS.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Belinky</LastName><ForeName>Paula A</ForeName><Initials>PA</Initials><AffiliationInfo><Affiliation>MIGAL-Galilee Technology Center, Kiryat Shmona 10200, Israel.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Flikshtein</LastName><ForeName>Nufar</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Lechenko</LastName><ForeName>Sergey</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Gepstein</LastName><ForeName>Shimon</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Dosoretz</LastName><ForeName>Carlos G</ForeName><Initials>CG</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Appl Environ Microbiol</MedlineTA><NlmUniqueID>7605801</NlmUniqueID><ISSNLinking>0099-2240</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003470">Culture Media</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017382">Reactive Oxygen Species</NameOfSubstance></Chemical><Chemical><RegistryNumber>E0399OZS9N</RegistryNumber><NameOfSubstance UI="D000242">Cyclic AMP</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.11.1.-</RegistryNumber><NameOfSubstance UI="D010544">Peroxidases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.11.1.-</RegistryNumber><NameOfSubstance UI="C042858">lignin peroxidase</NameOfSubstance></Chemical><Chemical><RegistryNumber>S88TT14065</RegistryNumber><NameOfSubstance UI="D010100">Oxygen</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D003470" MajorTopicYN="N">Culture Media</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000242" MajorTopicYN="N">Cyclic AMP</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004790" MajorTopicYN="N">Enzyme Induction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015966" MajorTopicYN="N">Gene Expression Regulation, Fungal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018384" MajorTopicYN="Y">Oxidative Stress</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010100" MajorTopicYN="N">Oxygen</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010544" MajorTopicYN="N">Peroxidases</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020075" MajorTopicYN="N">Phanerochaete</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName><QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017382" MajorTopicYN="N">Reactive Oxygen Species</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014158" MajorTopicYN="N">Transcription, Genetic</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate 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Dosoretz</name><name sortKey="Flikshtein, Nufar" sort="Flikshtein, Nufar" uniqKey="Flikshtein N" first="Nufar" last="Flikshtein">Nufar Flikshtein</name><name sortKey="Gepstein, Shimon" sort="Gepstein, Shimon" uniqKey="Gepstein S" first="Shimon" last="Gepstein">Shimon Gepstein</name><name sortKey="Lechenko, Sergey" sort="Lechenko, Sergey" uniqKey="Lechenko S" first="Sergey" last="Lechenko">Sergey Lechenko</name></noCountry><country name="Israël"><noRegion><name sortKey="Belinky, Paula A" sort="Belinky, Paula A" uniqKey="Belinky P" first="Paula A" last="Belinky">Paula A. Belinky</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:14602606" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PhanerochaeteV1
| This area was generated with Dilib version V0.6.37. |  |